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KMID : 0613820060160050788
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Journal of Life Science
2006 Volume.16 No. 5 p.788 ~ p.793
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Studies on Antioxidant Activity and Inhibition of Nitric Oxide Synthesis from Codium fragile
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Kim Yu-Jung
Jung Il-Sun
Choi Young-Ju
Choi In-Soon
Gal Sang-Wan
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Abstract
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This study was carried out to investigate the biological effects from Codium fragile. Methanol extract of Codium fragile increased two times at 2500 ㎍/ml the growth of Lactobacillus plantarum that associated with probiotic properties of lactic acid bacteria of Kimchi. Ethyl acetate extract of Codium fragile inhibited the cellulase activity up to approximately 60% at 2500 ㎍/ml. Methanol extract of Codium fragile was fractionated into several subfractions and their antioxidant activities were measured by using DPPH radical scavenging and SOD-like activity. Especially the antioxidative activity of ethyl acetate fraction was shown higher than that of other fractions and its fraction showed higher contents of total phenolic compounds, indicating the positive relationship between DPPH radical scavenging effect and total polyphenol content. Stimulation of the macrophages RAW264.7 cells with lipopolysaccharide (LPS) resulted in increased production of nitric oxide (NO) in the medium. However, the methanol extract of Codium fragile showed marked inhibition of NO synthesis in a dose-dependent manner. This result suggest that Codium fragile plays significant role for activation of immune system in the pathogenesis of inflammatory diseases.
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KEYWORD
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Codium fragile, phenolic compound, antioxidant, nitric oxide
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